Twenty five years ago, Dr. Batsheva Kerem and Dr. Eitan Kerem made a significant contribution to the scientific world’s understanding of genetic mutations and cystic fibrosis. Together—with their medical-research teams—they mapped the genetic mutation profile of cystic fibrosis among different Jewish ethnic groups in Israel. Since then, life expectancy for individuals with cystic fibrosis has shifted dramatically, thanks in part to their medical and genetic research and ongoing commitment to fighting the disease. These Israeli doctors, long married, represent two of the world’s major cystic fibrosis research centers: the Hadassah Medical Organization and Hebrew University. Today, the Kerems’ research serves as a map for the genetic counseling many Jewish couples undergo before having children.